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The goal of this book is to introduce the biological and technical aspects of next generation sequencing methods, as well as algorithms to assemble these sequences into�whole genomes. The book is organized into two parts; part 1 introduces NGS methods and part 2 reviews assembly algorithms and gives a good insight to these methods for readers new to the field. Gathering information, about sequencing and assembly methods together, helps both biologists and computer scientists to get a clear idea about the field.�Chapters will include information about new sequencing technologies such as ChIp-seq, ChIp-chip, and De Novo sequence assembly. ​

• Sales Rank: #2268326 in Books
• Published on: 2013-06-30
• Released on: 2013-06-30
• Original language: English
• Number of items: 1
• Dimensions: 9.25" h x .23" w x 6.10" l, .35 pounds
• Binding: Paperback
• 86 pages

Most helpful customer reviews

0 of 0 people found the following review helpful.
A Short Introduction to Sequencing
By Dr. Terrence McGarty
The test by Nejad et al is one of the Springer texts called Briefs in Systems Biology. This book is brief, less than 80 pages. Simply stated it covers four areas:

1. Classic Sanger approaches to reading DNA
2. Next Gen approaches including the Illumina and other now current systems
3. Collection of segments and purging them
4. Assembling the segments into ordered sequences

Overall the book is brief, it mentions most areas, the presentation is reasonable. If one has been exposed to the material and understands most of the key factors the book presents an outline of the issues you should be concerned with. It is in no way something to learn from. Nor was it touted to be such. Its descriptions are quite brief. For example the Illumina technique is explained in one page of text and one graphic. If you know the answer then the presentation presents another view. If, however, you are new to this, you most likely will not gain a great deal. Again the title expresses the fact that this is a Brief.

This book can be used to layout for many the areas that they should be focused on and then one is left to seek out other materials. For example Chapter 4 discusses many of the algorithms used to assemble a genome. This is an exceptionally high level presentation and if you understand the issues then it can provide an interesting context. If you do not understand the issue one may quickly get lost. The graph theory approach really requires that one understands graph theory and that is a level of depth well beyond the text. Also there are many probabilistic approaches that the authors do not get into.

The authors do discuss some of the pros and cons of the techniques but all too often there are strong schools of thought in each area.

Overall the book has value and for those working around the edges and understanding of the issue it may help provide additional directions to explore. As a stand-alone text, it is what it is, a Brief.

The book would strongly benefit from a list of terms defined. For the inexperienced reader there are many terms the authors assume are well known but that the target audience may need help with. The graphics are dense and again if you have seen versions of them before they are fine but if it is your first time seeing the descriptions then more space and detail may be needed.

2 of 3 people found the following review helpful.
Poorly edited mixed bag
By Andrew Veale
Don't bother buying this book.

I am beginning a postdoc in molecular ecology involving some next-gen work, and I thought that it would be nice to have a light overview of next-gen techniques. I have a good understanding of genetics, but wanted a concise update on next-gen techniques covering the basics to make sure I have a good general understanding. This is obviously what the book is meant to be, however it fails at the task.

A great deal of it is at the extremely basic level which wikipedia deals with as well (better). When it does focus on more technical aspects it doesn't explain them clearly, and you must then go and look up terms that are never defined in the text. I would recommend a browse through wikipedia above this book.

Also, throughout there are grammatical errors - which generally are interpretable, however it does detract from the understanding and flow. There are a few sentences that make no sense and I have no idea what the authors meant.

This field is moving very rapidly, and while it would be nice to have a concise overview of the topics, this probably doesn't exist yet.

0 of 1 people found the following review helpful.
Very good primer
By A Reading Shrink
For a statistical geneticist mainly studying association of SNPs with disease, NGS is a black box. This very concise and well referenced book gives an excellent bird's eye view of sequence technologies and assembly methods, with due regard to error possibilities. The links to public information sources are very useful. However, some of the links contain text and graphics present in the book, and not always clearly demarcated.

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[D383.Ebook] Download PDF Following the Trend: Diversified Managed Futures Trading, by Andreas Clenow

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During bull and bear markets, there is a group of hedge funds and professional traders which have been consistently outperforming traditional investment strategies for the past 30 odd years. They have shown remarkable uncorrelated performance and in the great bear market of 2008 they had record gains. �These traders are highly secretive about their proprietary trading algorithms and often employ top PhDs in their research teams. Yet, it is possible to replicate their trading performance with relatively simplistic models. These traders are trend following cross asset futures managers, also known as CTAs.� Many books are written about them but none explain their strategies in such detail as to enable the reader to emulate their success and create their own trend following trading business, until now.�
Following the Trend explains why most hopefuls fail by focusing on the wrong things, such as buy and sell rules, and teaches the truly important parts of trend following. Trading everything from the Nasdaq index and T-bills to currency crosses, platinum and lean hogs, there are large gains to be made regardless of the state of the economy or stock markets. By analysing year by year trend following performance and attribution the reader will be able to build a deep understanding of what it is like to trade futures in large scale and where the real problems and opportunities lay.
Written by experienced hedge fund manager Andreas Clenow, this book provides a comprehensive insight into the strategies behind the booming trend following futures industry from the perspective of a market participant. The strategies behind the success of this industry are explained in great detail, including complete trading rules and instructions for how to replicate the performance of successful hedge funds. You are in for a potentially highly profitable roller coaster ride with this hard and honest look at the positive as well as the negative sides of trend following.

• Sales Rank: #296579 in Books
• Published on: 2013-01-14
• Original language: English
• Number of items: 1
• Dimensions: 9.20" h x .85" w x 6.25" l, 1.25 pounds
• Binding: Hardcover
• 300 pages

Review

“Following the Trend is an absolute must read for anyone with an interest in systematic trend following whether as an investor, trader, or aspiring manager. The book is at the same time comprehensive and easy to read. As someone who has designed these types of systems, it is absolutely clear to me that Clenow writes as a knowledgeable practitioner, not an armchair theoretician. I admired Clenow’s repeatedly pointing out real life difficulties and drawbacks and his refusal to use optimization or well-chosen examples as virtually all other books of this type tend to do. In short, this is a real life presentation of the subject matter. In one particularly innovative chapter, Clenow creates close replications of some of the best and largest trendfollowing funds by combining his set of simple, non-optimized rules with variations in portfolio composition and volatility level.”—Jack Schwager, Author of Market Wizard and Schwager on Futures series and Market Sense and Nonsense

From the Inside Flap

“Andreas Clenow has written a very unique book that provides a rare insight into how an actual CTA hedge fund manager trades. Backing up all his claims with hard research, he cuts right to the point and educates the reader about how the real value of trend-following futures trading is achieved and how to replicate the success of the major hedge funds. A must read and an essential part of any serious trader's library!”—Carl Gyllenram, CEO, Ability Asset Management / Author of Trading with Crowd Psychology�

“Following the Trend truly captures what it is to be a systematic manager day in and day out. It is a must read for someone with ambitions to create his own systematic fund; highly recommended for everyone who is planning to invest in or understand the intricacies of systematic strategies.”—Sanjiv Kumar, Principal, Fort LP.

“In this excellent work, Andreas has shed light on some very important and previously undocumented aspects of trend following.� This book should be of great interest to Managed Futures managers and investors alike.”—Nigol Koulajian, Founder, Quest Partners, LLC

“This is must read for anyone involved in trading markets.� The thoughtful analysis of how models work and fail will help anyone interested in trading futures. This book adds to the short list of intelligent analysis available for investors to beat the market.”—Robert Savage, CEO, Track.com

“If you want to trade professionally by managing other people’s money, then this is one of the first books I recommend that you read.”—Van K. Tharp, Ph.D., Author, Trade Your Way to Financial Freedom, Supertrader and The Definitive Guide to Position Sizing Strategies

“Trend following is the largest sub-category of managed futures, driven by the market environment of price persistence. �Andreas has taken a complicated topic and provided an insightful viewpoint.”—Mark H. Melin, Author, High-Performance Managed Futures / Editor, Opalesque Futures Intelligence

“A no- nonsense view into the real world of trend following and how it can be done.”—Kathryn M. Kaminski, PhD, CIO and Founder, Alpha K Capital

From the Back Cover
During bull and bear markets, there is a group of hedge funds and professional traders which have been consistently outperforming traditional investment strategies for the past 30-odd years. They have shown remarkable uncorrelated performance and in the great bear market of 2008 they had record gains. �These traders are highly secretive about their proprietary trading algorithms and often employ top PhD's in their research teams. Yet, it is possible to replicate their trading performance with relatively simplistic models. These traders are trend following cross asset futures managers, also known as CTAs.� Many books are written about them but none explain their strategies in such detail as to enable the reader to emulate their success and create their own trend-following trading business.
Following the Trend explains why most fail by focusing on the wrong things, such as buy and sell rules, and teaches the truly important parts of trend following. Trading everything from the Nasdaq index and T-bills to currency crosses, platinum and lean hogs, there are large gains to be made regardless of the state of the economy or stock markets. By analysing year-by-year trend-following performance and attribution the reader will be able to build a deep understanding of what it is like to trade futures at a large scale and where the real problems and opportunities lay.
Written by experienced hedge fund manager Andreas Clenow, this book provides a comprehensive insight into the strategies behind the booming trend-following futures industry from the perspective of a market participant. The strategies behind the success of this industry are explained in great detail, including complete trading rules and instructions for how to replicate the performance of successful hedge funds.
The companion website for the book, FollowingTheTrend.com, is an information rich resource for futures traders with additional information, tools and continuous updates on the state of global trend following.

Most helpful customer reviews

61 of 64 people found the following review helpful.
This book brings trend following all together
By ASmith
The best summary of this book is in the foreword by Curtis Faith, original turtle trader. He recommends to budding trend followers that they first read Reminiscences of a Stock Operator to learn about Jesse Livermore. The original and the best. Then read Jack Schwager's Market Wizards books to learn about other successful traders and trend followers. Then, when you are truly ready to pull it all together into a coherent strategy, read Following the Trend by Andreas F Clenow.

I would personally read Trend Following by Michael Covel before this book, but that's just me. I've known about the turtle rules for a while now, and have backtested hundreds if not thousands of variations of it before reading Following the Trend. Although I am not a CTA nor am I live trading a diversified futures trend following strategy, almost every issue that I've thought about in the past is addressed in this book. Really. From what to do about contract rolls, to what markets to choose, Clenow shows that he's not just some author trying to make a buck. He's been there and done that. His thoughts and solutions only come from personal experience in trading this system. In particular there's a lot of information in here regarding running a fund. This is a book not just for the individual trader but especially for the would-be fund manager.

Before reading this book, I thought I pretty much had all the turtle/donchian channel/moving average concepts down. I didn't think there was really any knowledge that I lacked in getting the strategy up and running. I still found myself underlining a ton of this book, and realize now that I had plenty of gaps in my knowledge of diversified futures trading. This should be required reading material for anyone wanting to get into this type of strategy or business. Clenow is a pro, and I think it's rare for someone who has obvious experience in this business to share step by step what it takes to be a trend following fund.

27 of 30 people found the following review helpful.
Real deal trend following manual for pro's
By Amazon Customer
Been trading Forex since 2005 and I have read many so called books on trend following but this books knocks it out he park, even though its geared toward larger size institutional level players the historical analysis and strategies you will see professionals use here are truly an eye opener. I have not seen anyone break the data down like this and provide some simple ideas one can play with and test. I am happy to have found this work and a real professional in the industry sharing some knowledge with the small players out there. This is not a one read and your done type book its something you can study and assimilate over time. Then again its said you can publish the rules to the holy grail in the news paper, and no one would follow it. The book touches on so many things I was wondering about like money management, trend filtering, breakouts, and diversifying correctly.

24 of 27 people found the following review helpful.
I wish this book was ONLY written for me
By antonio_zeus
This is my first book review, and as the title shows - I wish this book was ONLY written for me. This is truly one of the best books I have read on trend following, risk management, backtesting and on running a managed fund.

You should be lucky enough to ever get this much information in one book - as opposed to Michael Covel's books, which lead to bits and pieces being given over time. You truly cannot compare the level of Andreas Clenow vs Michael Covel.. it is that far apart.

The in depth analysis of every year the strategy was being implemented over, clearly shows his understanding and frame of mind needed to execute such a strategy. Andreas Clenow manages money, Michael Covel has never managed money.

It's very simple and Richard Dennis said it best: "I always say that you could publish your trading rules in the newspaper and no one would follow them." The author of this book proves that with the year to year analysis in addition to the psychology needed to prepare for the kind of results trend followers REALLY experience.

I will not give more information than that.. like I said, I wish this was only written for my eyes to see.

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• Sales Rank: #10588497 in Books
• Published on: 1991-10
• Original language: Spanish
• Number of items: 1
• Binding: Hardcover

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Upgrading & Repairing Servers (06) by Mueller, Scott - Soper, Mark Edward - Sosinsky, Barrie [Hardcover (2006)]

• Published on: 2006
• Binding: Hardcover

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[X343.Ebook] PDF Ebook The Preacher's Son #1: Unbound, by Jasinda Wilder

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I showed up in backwater little Yazoo City Mississippi expecting to find solitude and a fresh start. I just left my wealthy, neglectful husband--with a couple million dollars belonging to him, I might add. When I got to Yazoo, though, I didn't find any solitude, that's for sure. I ended up in the arms of an oh so sexy man named Tre McNabb. The problem? Tre is the preacher's son.�
Don't miss the next parts of The Preacher's Son story: The Preacher's Son 2: Unleashed and The Preacher's Son 3: Unbroken (Now available).**This is an explicit, erotic novella for adults only! Contains super hot, one on one sex between two great characters.**

• Published on: 2012-08-29
• Released on: 2012-08-29
• Format: Kindle eBook

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7 of 9 people found the following review helpful.
horrible
By cristina
Horrible. I read it to get it over. How can a man that is a virgin be the best sex ever??? Ladies place answer that for me lol!!!!!!!! ****************

4 of 5 people found the following review helpful.
Fast sexy start
By Wendy Racine
This was such a fast but sexy start to the series. I liked the fact that Tre was so young and innocent cause that made him more appealing to me. Shea was an interesting character-I wanted to know more about her past and why she ran but I feel that all that baggage will come in good time. I was surprised that the story was that fast-paced but it was good. The attraction and tension can definitely be felt as you were reading it. The only thing that I wanted more was a little more story besides all the action but I still thought it was pretty good.

2 of 2 people found the following review helpful.
Good
By K.Sher
The time frame was surprisingly short. I was hoping to get to know the characters a bit. Hot sex, though.

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[S505.Ebook] PDF Ebook Happiness Is . . . 500 Ways to Show I Love You, by Lisa Swerling, Ralph Lazar

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From the creators of Happiness Is... (more than 100,000 copies in print!), this adorable gift book illustrates 500 ways to share the love with that special someone. Capturing the extraordinary little moments and feelings that make up true love, this is the perfect gift for Valentine's Day, anniversaries, or just to say "I Love You."

• Sales Rank: #72250 in Books
• Published on: 2016-09-13
• Released on: 2016-09-13
• Original language: English
• Number of items: 1
• Dimensions: 6.00" h x 1.00" w x 6.25" l, .0 pounds
• Binding: Paperback
• 272 pages

About the Author
Lisa Swerling and Ralph Lazar are famed illustrators, authors of the New York Times bestseller Me Without You, and the creators of the internationally popular brand Happiness Is .... They live in Marin County, California.

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[M960.Ebook] Ebook Download Fiber Menace: The Truth About the Leading Role of Fiber in Diet Failure, Constipation, Hemorrhoids, Irritable Bowel Syndrome, Ulcerative Co

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• Sales Rank: #133225 in Books
• Published on: 2008-10-15
• Original language: English
• Number of items: 1
• Dimensions: 9.00" h x .67" w x 6.00" l,
• Binding: Paperback
• 296 pages

Review
My training as a physician included many hours of nutrition, but fiber was only mentioned in regards to the effects of a deficiency. Never once did any of my professors consider the possibility that too much of what has always been considered a good thing' could have such harmful or far-reaching consequences. The author's detailed description of the trauma imposed to the gastrointestinal mucosa by the expanding fiber is a vivid reminder that returning to the basics of GI function and logically thinking through what our bodies actually are designed to do with the food we eat, should be the first step on anyone's journey to recovery from digestive disorders. Thanks to the insights in this book I have slowly begun to change my approach to common patient symptoms, which I traditionally would have treated by suggesting increased fiber and more water to correct! So far the results are promising. Dr. John Turner, DC, CCSP, DIBCN --Wise Traditions Newsletter by Weston A. Price foundation

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8 of 8 people found the following review helpful.
Saved my life
By Anna Nilssen
Have had diverticulitis for 10 years now. Have listed to the Doctors who said , increase fiber.....more water...Never has any doctor told me I was peeing away essential vitamins . Never told to take probiotics to replace the gut flora damaged by all the antibiotics I was given.....I just was admitted to the hospital and had 5 days of high dose antibiotics........At this time I found this book "Fiber Menace" to read......I am sooooo angry at the lack of info the Doctors gave me and immediately wanted to do surgery.
I said no because I felt doing gut surgery when you have a leak into the gastric cavity while so infected is stupid and asking to become septic. It has been two weeks on my new low fiber way of life...I now go three times a day without pushing at all. Any greens I eat now are juiced to a fine drink......I feel great. Am also doing the probiotics with the magnesium and potassium . This is the first time in 10 years I have not used stool softners, enemas, laxatives to just go to the bathroom......I am a happy happy camper.
Thanks for making the book easy to read so that anyone can understand gut sense.....

2 of 2 people found the following review helpful.
Turns conventional fiber-wisdom on its head - and he might be right
By B. L. Hartway
If you are like me, you have heard all the buzz about how important and healthy fiber is for your diet. Doctors and Nutritionists and Health researchers and every other commercial on TV tell us that we just can't get enough fiber in our diet, and we should get more to be healthier.
Seems like almost everyone agrees. Seems like no one questions this advice. Seems like everyone has been reading and hearing and seeing the same 'facts', and assumes this advice to be gospel.
Turns out that this may not be true, if this author is correct in his contrarian, independent research. I call him "the crazy Russian", since he seems to be the only person I have ever run across who shows research (his own, plus other's) that turns this idea on its head.
I call him "crazy", since he seems to be a voice in the wilderness, and at first his claims that fiber is always healthy, and can in fact be bad for your health, depending upon what, when, and how you use different kinds of fiber. Can he possibly be right, and everyone else wrong. He must be crazy. Wrong.
I am a retired research scientist, and although I am not a health expert, I can follow his claims, research, and logic, and honestly feel that he is probably right. Namely, the unquestioned conventional wisdom about 'you can't get enough fiber' is wrong and dangerous. There are many kinds of fiber, and you must choose the right kind, use the right amount, and in the right way, if you want to stay healthy.
He does a nice job of explaining this, and how 'conventional wisdom facts' have been improperly researched and verified over decades.
He explains how he thinks is the proper fibers to use, and why, and the proper ways to use it, for best health benefit.
I for one think the author is correct, and conventional health industry practice has been wrong all these years. So read what he says, and decide for yourself - it may change your health for the better. It is at the least worth thinking about and trying.

2 of 2 people found the following review helpful.
Must-read for Everyone!
By Linda BkReviews
This is an extremely useful book. Whether you suffer from any digestive ailment or not, I believe this to be a must-read for everyone.

I had suffered from constipation for years. Eating more fiber as according to “conventional wisdom” only led to more flatulence, more discomfort and even harder, larger stool that refused to budge. Such “advice” caused even more harm, pain and emotional stress than ever. It took me a long time to finally come to the conclusion that insoluble fiber was making things worse, and that I should stop stuffing myself with whole grain, flower seeds and especially, never again, bran.

This book offers a lot of research results and gives readers genuine and feasible guidelines to reverse the damages that fiber has already done to the body, or in the case of healthy readers, help prevent digestive disorders.

Even if you are not interested in the researches, the step-by-step guides to restoring flora in your guts really work. I now have toilet habits that are more or less regular, and most importantly, 100% painless and effortless.

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[G728.Ebook] Free Ebook Private Lies: Infidelity and the Betrayal of Intimacy

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• Published on: 1800
• Binding: Paperback

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[C930.Ebook] Ebook Download Assistive Technologies for People with Diverse Abilities (Autism and Child Psychopathology Series)From Springer

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The familiar image of the disabled tends to emphasize their limitations and reduced quality of life. However, many people with cognitive, motor, and other difficulties also have the capacity to enhance their social interactions, leisure pursuits and daily activities with the aid of assistive technology. Assistive devices from the simple to the sophisticated, have become essential to intervention programs for this population. And not surprisingly the numbers of devices available are growing steadily.

Assistive Technologies for People with Diverse Abilities offers expert analysis of pertinent issues coupled with practical discussion of solutions for effective support. Its comprehensive literature review describes current and emerging devices and presents evidence-based guidelines for matching promising technologies to individuals. Program outcomes are assessed, as are their potential impact on the future of the field. In addition, chapters provide detailed descriptions of the personal and social needs of the widest range of individuals with congenital and acquired conditions, including:

• Acquired brain damage.
• Communication impairment.
• Attention and learning difficulties (with special focus on college students).
• Visual impairment and blindness.
• Autism spectrum disorders.
• Behavioral and occupational disorders.
• Alzheimer's disease.
• Severe, profound and multiple impairments.

The scope and depth of coverage makes Assistive Technologies for People with Diverse Abilities an invaluable resource for researchers, professionals and graduate students in developmental psychology, rehabilitation medicine, educational technology, occupational therapy, speech pathology and clinical psychology.

• Sales Rank: #3070369 in Books
• Published on: 2014-01-09
• Original language: English
• Number of items: 1
• Dimensions: 9.21" h x .81" w x 6.14" l, 1.45 pounds
• Binding: Hardcover
• 326 pages

Review

From the book reviews:

“This book summarizes current research on what devices are available for specific disabilities, how they have been used, and what the results were. It is difficult to overstate how rich this book is. It will change the way clinicians think and work with such individuals. This is an extremely important book for those who are involved in the lives of individuals with diverse abilities, but are also experiencing needs in other areas.” (Ramasamy Manikam, Journal of Child and Family Studies, Vol. 23, 2014)

From the Back Cover

The familiar image of the disabled tends to emphasize their limitations and reduced quality of life. However, many people with cognitive, motor, and other difficulties also have the capacity to enhance their social interactions, leisure pursuits, and daily activities with the aid of assistive technology. Assistive devices, from the simple to the sophisticated, have become essential to intervention programs for this population. And not surprisingly, the numbers of devices available are growing steadily.

�

Assistive Technologies for People with Diverse Abilities offers expert analysis of pertinent issues coupled with practical discussion of solutions for effective support. Its comprehensive literature review describes current and emerging devices and presents evidence-based guidelines for matching promising technologies to individuals. Program outcomes are assessed, as are their potential impact on the future of the field. In addition, chapters provide detailed descriptions of the personal and social needs of the widest range of individuals with congenital and acquired conditions, including:

�

• Acquired brain damage.
• Communication impairment.
• Attention and learning difficulties (with special focus on college students).
• Visual impairment and blindness.
• Autism spectrum disorders.
• Behavioral and occupational disorders.
• Alzheimer's disease.
• Severe, profound, and multiple impairments.

�

The scope and depth of coverage makes Assistive Technologies for People with Diverse Abilities an invaluable resource for researchers, professionals, and graduate students in developmental psychology, rehabilitation medicine, educational technology, occupational therapy, speech pathology, and clinical psychology.

�

About the Author

Giulio E. Lancioni, Ph.D., is Professor in the Department of Neuroscience and Sense Organs, University of Bari, Italy. Prior to this position, he spent many years at the Department of Psychology, University of Leiden, The Netherlands.�His research interests include development and assessment of assistive technologies, training of social and occupational skills and evaluation of strategies for examining preference and choice with individuals with severe/profound intellectual and multiple disabilities (including post-coma persons in a minimally conscious state and persons with Alzheimer's disease).�He has published widely in these areas and serves in the editorial board of several international journals concerned with these topics.

Nirbhay N. Singh, Ph.D., BCBA-D, is Clinical Professor of Psychiatry and Health Behavior at the Medical College of Georgia, Georgia Regents University, Augusta, Georgia, USA. Prior to his current appointment, he was a Professor of Psychiatry, Pediatrics and Psychology at the Virginia Commonwealth University School of Medicine and Director of the Commonwealth Institute for Family Studies, Richmond, Virginia. His research interests include mindfulness, behavioral and psychopharmacological treatments of individuals with disabilities and assistive technology for supporting individuals with severe/profound and multiple disabilities. He is the Editor-in-Chief of two journals: Journal of Child and Family Studies and Mindfulness and Editor of three book series: Mindfulness in Behavioral Health, Evidence-based Practice in Behavioral Health and Children and Families.

Most helpful customer reviews

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Four Stars
By Kenya Engram
Very informative about assistive technologies for disabilities.

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